A COMPLETE RESPONSE TO COMBINED IMMUNOTHERAPY IN A PATIENT WITH AN ATM PLUS SF3B1 MUTATION AND A MODERATE TUMOR MUTATIONAL BURDEN WITH A HIGH-GRADE TREATMENT-EMERGENT NEUROENDOCRINE PROSTATE CANCER: CASE REPORT AND REVIEW OF THE LITERATURE

Introduction: High-grade treatment-emergent neuroendocrine prostate cancer (T-NEPC) is a rare subtype of prostate cancer with limited therapeutic options and poor prognosis.Understanding biomarkers that influence the efficacy of immune checkpoint inhibitors (IO) is vital to form a better therapeutic arsenal for these patients.Case Presentation: We

Phylogeographic patterns and sex-biased dispersal were studied in riverine populations of West Indian (Trichechus manatus) and Amazonian manatees (T.inunguis) in South America, using 410bp D-loop (Control Region, Mitochondrial DNA) sequences and 15 nuclear microsatellite loci.This multi-locus approach was key to disentangle complex patterns of gene

Production-oriented firms need operational as well as financial working capital to sustain the business in a competitive environment.However, firms in underdeveloped countries face many issues in meeting the capital and revenue nature AFTER SUN BALM expenditure.Due to this issue these firms arrange capital from other sources like seed money.The fin

This article examines the foreign policy platform of Donald Trump, based on his proposals, the composition of his advisers and supporting coalitions.Second focus of the article is the internal political context and limitations to the new administration of the White House.Finally, there are conclusions for Russia and possible scenarios for the devel

Tropical species are Chandelier widely used in construction, and their physical and mechanical properties have been important characteristics with direct impact on the design of structures, especially the strength and stiffness of wood applied in them.Tests to obtain both parameters are conducted under ABNT NBR 7190 (1997) guidelines in Brazil, bei